Back to Search Start Over

Action of Acetaldehyde on Glucose Metabolism of Newborn and Adult Erythrocytes

Action of Acetaldehyde on Glucose Metabolism of Newborn and Adult Erythrocytes

Authors :
Ninfali, Paolino
Palma, Fulvio
Piacentini, Maria Piera
Fornaini, Giorgio
Source :
Biology of the Neonate; January 1987, Vol. 52 Issue: 5 p256-263, 8p
Publication Year :
1987

Abstract

This paper reports the effect of acetaldehyde on erythrocytes (RBC) of human adults and newborns. Acetaldehyde increases glucose consumption in adult RBC, but has no effect on that of newborn RBC. The compound stimulates the hexose monophosphate shunt and decreases the pyruvate production of the two RBC suspensions. In newborn RBC, acetaldehyde slightly modifies triose-P and fructose-1,6-bisphosphate but has no effect on the ATP/ADP ratio and glucose-1,6-bisphosphate content, which change markedly in adult RBC. Analysis of aldehyde dehydrogenase reveals nearly one half of enzyme activity in newborn RBC. The data indicate that in both adult and newborn RBC, acetaldehyde causes an intracellular reduced state, but the newborn cells take advantage of their greater pyruvate production for complete removal of the exceeding NADH equivalents.

Details

Language :
English
ISSN :
00063126 and 14219727
Volume :
52
Issue :
5
Database :
Supplemental Index
Journal :
Biology of the Neonate
Publication Type :
Periodical
Accession number :
ejs59076642
Full Text :
https://doi.org/10.1159/000242717