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Comparison of the Appropriateness of the Latex and Elisa Plasma D-Dimer Determination for the Diagnosis of Deep Venous Thrombosis
- Source :
- Haemostasis; January 1991, Vol. 21 Issue: 2 p106-110, 5p
- Publication Year :
- 1991
-
Abstract
- Thirty-two patients suspected of deep venous thrombosis (DVT) of the leg were evaluated after simple plasma tests (latex D-dimer and Elisa D-dimer) against echography and phlebography as the gold standard of DVT. Seven patients showed negative results in the latter test. The classification conformity between the D-dimer methods amounted 84.4%. With regard to the diagnostic classification a high specificity of 100% was found for the latex D-dimer test at the cut-off level of 450 ng/ml, whereas for sensitivity, 96% was reached. The Elisa D-dimer test was striking by its high sensitivity of 100%, but its low specificity of 28.5 %. In summary, these results demonstrate that when there is a suspicion of DVT according to the clinical symptoms, a negative latex test may reject the diagnosis, whereas the latex test is less useful to establish the diagnosis. On the contrary, the Elisa .D-dimer test has a too high false-positive rate. The latex D-dimer test seems to be a reliable tool to exclude the diagnosis after which an ascending contrast venography can be omitted.
Details
- Language :
- English
- ISSN :
- 03010147 and 14230038
- Volume :
- 21
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Haemostasis
- Publication Type :
- Periodical
- Accession number :
- ejs59073629
- Full Text :
- https://doi.org/10.1159/000216212