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Unreliability of Chromogenic Substrates for Assay of the Clotting Activity of Thrombin

Authors :
Gaffney, Patrick J.
Miller-Andersson, Maggie
Kirkwood, Tom B.L.
Source :
Haemostasis; January 1978, Vol. 7 Issue: 2-3 p109-112, 4p
Publication Year :
1978

Abstract

The rapid loss in clotting activity of commercially available thrombins during storage is not reflected by their activity as measured by synthetic chromogenic substrates. It is suggested that conformational changes occurring during storage can affect the binding sites of thrombin for fibrinogen, whereas small synthetic substrates are incapable of monitoring these changes.

Details

Language :
English
ISSN :
03010147 and 14230038
Volume :
7
Issue :
2-3
Database :
Supplemental Index
Journal :
Haemostasis
Publication Type :
Periodical
Accession number :
ejs59072513
Full Text :
https://doi.org/10.1159/000214246