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Outcomes of Allogeneic Hematopoietic Cell Transplantation in T Cell Prolymphocytic Leukemia: A Contemporary Analysis from the Center for International Blood and Marrow Transplant Research
- Source :
- Transplantation and Cellular Therapy; April 2022, Vol. 28 Issue: 4 p187.e1-187.e10, 16840p
- Publication Year :
- 2022
-
Abstract
- •Allogeneic hematopoietic cell transplantation is effective in yielding durable remissions in patients with T cell prolymphocytic leukemia.•Myeloablative conditioning, age >60 years, and Karnofsky Performance Status <90 were associated with reduced overall survival (OS).•Reduced-intensity conditioning and avoidance of in vivo T cell depletion correlated with better disease-free survival (DFS) and lower treatment-related mortality (TRM).•Total body irradiation was found to have no significant effect on OS, DFS. or TRM.
Details
- Language :
- English
- ISSN :
- 26666375 and 26666367
- Volume :
- 28
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Transplantation and Cellular Therapy
- Publication Type :
- Periodical
- Accession number :
- ejs58746370
- Full Text :
- https://doi.org/10.1016/j.jtct.2022.01.017