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Outcomes of Allogeneic Hematopoietic Cell Transplantation in T Cell Prolymphocytic Leukemia: A Contemporary Analysis from the Center for International Blood and Marrow Transplant Research

Authors :
Murthy, Hemant S.
Ahn, Kwang Woo
Estrada-Merly, Noel
Alkhateeb, Hassan B.
Bal, Susan
Kharfan-Dabaja, Mohamed A.
Dholaria, Bhagirathbhai
Foss, Francine
Gowda, Lohith
Jagadeesh, Deepa
Sauter, Craig
Abid, Muhammad Bilal
Aljurf, Mahmoud
Awan, Farrukh T.
Bacher, Ulrike
Badawy, Sherif M.
Battiwalla, Minoo
Bredeson, Chris
Cerny, Jan
Chhabra, Saurabh
Deol, Abhinav
Diaz, Miguel Angel
Farhadfar, Nosha
Freytes, César
Gajewski, James
Gandhi, Manish J.
Ganguly, Siddhartha
Grunwald, Michael R.
Halter, Joerg
Hashmi, Shahrukh
Hildebrandt, Gerhard C.
Inamoto, Yoshihiro
Jimenez-Jimenez, Antonio Martin
Kalaycio, Matt
Kamble, Rammurti
Krem, Maxwell M.
Lazarus, Hillard M.
Lazaryan, Aleksandr
Maakaron, Joseph
Munshi, Pashna N.
Munker, Reinhold
Nazha, Aziz
Nishihori, Taiga
Oluwole, Olalekan O.
Ortí, Guillermo
Pan, Dorothy C.
Patel, Sagar S.
Pawarode, Attaphol
Rizzieri, David
Saba, Nakhle S.
Savani, Bipin
Seo, Sachiko
Ustun, Celalettin
van der Poel, Marjolein
Verdonck, Leo F.
Wagner, John L.
Wirk, Baldeep
Oran, Betul
Nakamura, Ryotaro
Scott, Bart
Saber, Wael
Source :
Transplantation and Cellular Therapy; April 2022, Vol. 28 Issue: 4 p187.e1-187.e10, 16840p
Publication Year :
2022

Abstract

•Allogeneic hematopoietic cell transplantation is effective in yielding durable remissions in patients with T cell prolymphocytic leukemia.•Myeloablative conditioning, age >60 years, and Karnofsky Performance Status <90 were associated with reduced overall survival (OS).•Reduced-intensity conditioning and avoidance of in vivo T cell depletion correlated with better disease-free survival (DFS) and lower treatment-related mortality (TRM).•Total body irradiation was found to have no significant effect on OS, DFS. or TRM.

Details

Language :
English
ISSN :
26666375 and 26666367
Volume :
28
Issue :
4
Database :
Supplemental Index
Journal :
Transplantation and Cellular Therapy
Publication Type :
Periodical
Accession number :
ejs58746370
Full Text :
https://doi.org/10.1016/j.jtct.2022.01.017