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Palladium-catalyzed Hiyama cross-couplings of 2-chloro pyrimidines with organosilanes
- Source :
- Chemical Papers; 20220101, Issue: Preprints p1-7, 7p
- Publication Year :
- 2022
-
Abstract
- An efficient synthesis of C2-aryl pyrimidine derivatives via Pd-catalyzed Hiyama couplings has been developed. Various 2-chloro pyrimidines with electron-donating or electron-withdrawing groups as novel electrophile partners coupled well with trimethoxy(phenyl)silane and vinyltrimethoxysilane in the presence of CuCl and TBAF, providing desired products in good to excellent yields. This procedure showed good functional group tolerance, and the electronic and steric effects of 2-chloro pyrimidines seem to be negligible for the transformation.
Details
- Language :
- English
- ISSN :
- 25857290 and 13369075
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Chemical Papers
- Publication Type :
- Periodical
- Accession number :
- ejs58666202
- Full Text :
- https://doi.org/10.1007/s11696-021-02044-5