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A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma

Authors :
Sahasrabuddhe, Anagh Anant
Chen, Xiaofei
Ma, Kaiyu
Wu, Rui
Kapoor, Richa
Chhipa, Rishi Raj
Zhang, Xiao
Onder, Ozlem
Wilmore, Joel
Gaudette, Brian T.
Pillai, Vinodh
Li, Marilyn M.
Ahn, Joon-Young
Chung, Fuzon
Szankasi, Philippe
Basrur, Venkatesha
Conlon, Kevin P
Bailey, Nathanael G.
Hogaboam, Cory M
Rottapel, Robert
Kim, Junhyong
Lopez, Cristina
Seufert, Julian
Schlesner, Matthias
Siebert, Reiner
Cancro, Michael P
Allman, David
Pagano, Michele
Staudt, Louis M.
Lim, Megan S.
Elenitoba-Johnson, Kojo S.J.
Source :
Blood; November 2021, Vol. 138 Issue: 1, Number 1 Supplement 1 p711-711, 1p
Publication Year :
2021

Abstract

Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common form of malignant lymphoma and may arise deā€ˆnovo, or through transformation from a pre-existing low-grade B cell lymphoma such as follicular lymphoma (FL). However, the post-translational mechanisms and deregulated pathways underlying the pathogenesis of disease evolution are not fully understood.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
138
Issue :
1, Number 1 Supplement 1
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs58560656
Full Text :
https://doi.org/10.1182/blood-2021-151245