Possible epistatic role of <TOGGLE>ADH7</TOGGLE> in the protection against alcoholism

Authors :: Osier, M.V.
Lu, R.-B.
Pakstis, A.J.
Kidd, J.R.
Huang, S.-Y.
Kidd, Kenneth K.
Source :: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; 1 April 2004, Vol. 126 Issue: 1 p19-22, 4p
Publication Year :: 2004
Abstract: In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD). © 2003 Wiley-Liss, Inc.

Language :: English
ISSN :: 15524841 and 1552485X
Volume :: 126
Issue :: 1
Database :: Supplemental Index
Journal :: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics
Publication Type :: Periodical
Accession number :: ejs5843797
Full Text :: https://doi.org/10.1002/ajmg.b.20136

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