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Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial
Authors :
Verma, Subodh Dhingra, Nitish K Butler, Javed Anker, Stefan D Ferreira, Joao Pedro Filippatos, Gerasimos Januzzi, James L Lam, Carolyn S P Sattar, Naveed Peil, Barbara Nordaby, Matias Brueckmann, Martina Pocock, Stuart J Zannad, Faiez Packer, Milton Packer, M Anker, S Butler, J Filippatos, G Pocock, S Zannad, F Ferreira, JP Brueckmann, M George, J Jamal, W Welty, FK Palmer, M Clayton, T Parhofer, KG Pedersen, TR Greenberg, B Konstam, MA Lees, KR Carson, P Doehner, W Miller, A Haas, M Pehrson, S Komajda, M Anand, I Teerlink, J Rabinstein, A Steiner, T Kamel, H Tsivgoulis, G Lewis, J Freston, J Kaplowitz, N Mann, J Petrie, J Perrone, S Nicholls, S Janssens, S Bocchi, E Giannetti, N Verma, S Zhang, J Spinar, J Seronde, M-F Boehm, M Merkely, B Chopra, V Senni, M Taddi, S Tsutsui, H Choi, D-J Chuquiure, E La Rocca, HPB Ponikowski, P Juanatey, JRG Squire, I Januzzi, J Pina, I Bernstein, R Cheung, A Green, J Januzzi, J Kaul, S Lam, C Lip, G Marx, N McCullough, P Mehta, C Ponikowski, P Rosenstock, J Sattar, N Scirica, B Shah, S Tsutsui, H Verma, S Wanner, C Aizenberg, D Cartasegna, L Colombo Berra, F Colombo, H Fernandez Moutin, M Glenny, J Alvarez Lorio, C Anauch, D Campos, R Facta, A Fernandez, A Ahuad Guerrero, R Lobo Márquez, L Leon de la Fuente, RA Mansilla, M Hominal, M Hasbani, E Najenson, M Moises Azize, G Luquez, H Guzman, L Sessa, H Amuchástegui, M Salomone, O Perna, E Piskorz, D Sicer, M Perez de Arenaza, D Zaidman, C Nani, S Poy, C Resk, J Villarreal, R Majul, C Smith Casabella, T Sassone, S Liberman, A Carnero, G Caccavo, A Berli, M Budassi, N Bono, J Alvarisqueta, A Amerena, J Kostner, K Hamilton, A Begg, A Beltrame, J Colquhoun, D Gordon, G Sverdlov, A Vaddadi, G Wong, J Coller, J Prior, D Friart, A Leone, A Janssens, S Vervoort, G Timmermans, P Troisfontaines, P Franssen, C Sarens, T Vandekerckhove, H Van De Borne, P Chenot, F De Sutter, J De Vuyst, E Debonnaire, P Dupont, M Pereira Dutra, O Canani, LH Vieira Moreira, MdC de Souza, W Backes, LM Maia, L De Souza Paolino, B Manenti, ER Saporito, W Villaça Guimarães Filho, F Franco Hirakawa, T Saliba, LA Neuenschwander, FC de Freitas Zerbini, CA Gonçalves, G Gonçalves Mello, Y Ascenção de Souza, J Beck da Silva Neto, L Bocchi, EA Da Silveira, J de Moura Xavier Moraes Junior, JB de Souza Neto, JD Hernandes, M Finimundi, HC Sampaio, CR Vasconcellos, E Neves Mancuso, FJ Noya Rabelo, MM Rodrigues Bacci, M Santos, F Vidotti, M Simões, MV Gomes, FL Vieira Nascimento, C Precoma, D Helfenstein Fonseca, FA Ribas Fortes, JA Leães, PE Campos de Albuquerque, D Kerr Saraiva, JF Rassi, S Alves da Costa, FA Reis, G Zieroth, S Dion, D Savard, D Bourgeois, R Constance, C Anderson, K Verma, S Leblanc, M-H Yung, D Swiggum, E Pliamm, L Pesant, Y Tyrrell, B Huynh, T Spiegelman, J Giannetti, N Lavoie, J-P Hartleib, M Bhargava, R Straatman, L Virani, S Costa-Vitali, A Hill, L Heffernan, M Khaykin, Y Ricci, J Senaratne, M Zhai, A Lubelsky, B Toma, M Yao, L McKelvie, R Noronha, L Babapulle, M Pandey, A Curnew, G Lavoie, A Berlingieri, J Kouz, S Lonn, E Chehayeb, R Zheng, Y Sun, Y Cui, H Fan, Z Han, X Jiang, X Tang, Q Zhou, J Zheng, Z Zhang, X Zhang, N Zhang, J Zhang, Y Shen, A Yu, J Ye, J Yao, Y Yan, J Xu, X Wang, Z Ma, J Li, Y Li, S Lu, S Kong, X Song, Y Yang, G Yao, Z Zhang, J Zhang, Y Pan, Y Guo, X Sun, Z Dong, Y Zhu, J Peng, D Yuan, Z Lin, J Yin, Y Jerabek, O Burianova, H Fiala, T Hubac, J Ludka, O Monhart, Z Vodnansky, P Zeman, K Foldyna, D Krupicka, J Podpera, I Busak, L Radvan, M Vomacka, Z Prosecky, R Cifkova, R Durdil, V Vesely, J Vaclavik, J Cervinka, P Linhart, A Brabec, T Miklik, R Bourhaial, H Olbrich, H-G Genth-Zotz, S Kemala, E Lemke, B Böhm, M Schellong, S Rieker, W Heitzer, T Ince, H Faghih, M Birkenfeld, A Begemann, A Ghanem, A Ujeyl, A von Haehling, S Dorsel, T Bauersachs, J Prull, M Weidemann, F Darius, H Nickenig, G Wilke, A Sauter, J Rauch-Kroehnert, U Frey, N Schulze, CP König, W Maier, L Menzel, F Proskynitopoulos, N Ebert, H-H Sarnighausen, H-E Düngen, H-D Licka, M Marx, N Stellbrink, C Winkelmann, B Menck, N López-Sendón, JL de la Fuente Galán, L Delgado Jiménez, JF Manito Lorite, N Pérez de Juan Romero, M Galve Basilio, E Cereto Castro, F González Juanatey, JR Gómez, JJ Sanmartín Fernández, M Garcia-Moll Marimon, X Pascual Figal, D Bover Freire, R Bonnefoy Cudraz, E Jobbe Duval, A Tomasevic, D Habib, G Isnard, R Picard, F Khanoyan, P Dubois-Rande, J-L Galinier, M Roubille, F Alexandre, J Babuty, D Delarche, N Seronde, M-F Berneau, J-B Girerd, N Saxena, M Rosano, G Yousef, Z Clifford, C Arden, C Bakhai, A Squire, I Boos, C Jenkins, G Travill, C Price, D Koenyves, L Lakatos, F Matoltsy, A Noori, E Zilahi, Z Andrassy, P Kancz, S Simon, G Sydo, T Vorobcsuk, A Merkely, B Kiss, RG Toth, K Szakal, I Nagy, L Barany, T Nagy, A Szolnoki, E Chopra, VK Mandal, S Rastogi, V Shah, B Mullasari, A Shankar, J Mehta, V Oomman, A Kaul, U Komarlu, S Kahali, D Bhagwat, A Vijan, V Ghaisas, NK Mehta, A Kashyap, J Kothari, Y TaddeI, S Scherillo, M Zacà, V Genovese, S Salvioni, A Fucili, A Fedele, F Cosmi, F Volpe, M Senni, M Mazzone, C Esposito, G Doi, M Yamamoto, H Sakagami, S Oishi, S Yasaka, Y Tsuboi, H Fujino, Y Matsuoka, S Watanabe, Y Himi, T Ide, T Ichikawa, M Kijima, Y Koga, T Yuda, S Fukui, K Kubota, T Manita, M Fujinaga, H Matsumura, T Fukumoto, Y Kato, R Kawai, Y Hiasa, G Kazatani, Y Mori, M Ogimoto, A Inoko, M Oguri, M Kinoshita, M Okuhara, K Watanabe, N Ono, Y Otomo, K Sato, Y Matsunaga, T Takaishi, A Miyagi, N Uehara, H Takaishi, H Urata, H Kataoka, T Matsubara, H Matsumoto, T Suzuki, T Takahashi, N Imamaki, M Watanabe, N Yoshitama, T Saito, T Sekino, H Furutani, Y Koda, M Matsuoka, S Shinozaki, T Hirabayashi, K Tsunoda, R Yonezawa, K Hori, H Yagi, M Arikawa, M Hashizume, T Ishiki, R Koizumi, T Nakayama, K Taguchi, S Nanasato, M Yoshida, Y Tsujiyama, S Nakamura, T Oku, K Shimizu, M Suwa, M Momiyama, Y Sugiyama, H Kobayashi, K Inoue, S Kadokami, T Maeno, K Kawamitsu, K Maruyama, Y Nakata, A Shibata, T Wada, A Cho, H-J Na, JO Yoo, B-S Choi, J-O Hong, SK Shin, J-H Cho, M-C Han, SH Jeong, J-O Kim, J-J Kang, SM Kim, D-S Kim, MH Llamas Esperon, G Illescas Díaz, J Fajardo Campos, P Almeida Alvarado, J Bazzoni Ruiz, A Echeverri Rico, J Lopez Alcocer, I Valle Molina, L Hernandez Herrera, C Calvo Vargas, C Padilla Padilla, FG Rodriguez Briones, I Chuquiure Valenzuela, EJJR Aguilera Real, ME Carrillo Calvillo, J Alpizar Salazar, M Cervantes Escárcega, JL Velasco Sanchez, R Al - Windy, N van Heerebeek, L Bellersen, L Brunner-La Rocca, H-P Post, J Linssen, GCM van de Wetering, M Peters, R van Stralen, R Groutars, R Smits, P Yilmaz, A Kok, WEM Van der Meer, P Dijkmans, P Troquay, R van Alem, AP Van de Wal, R Handoko, L Westendorp, ICD van Bergen, PFMM Rensing, BJWM Hoogslag, P Kietselaer, B Kragten, JA den Hartog, FR Alings, A Danilowicz-Szymanowicz, L Raczak, G Piesiewicz, W Zmuda, W Kus, W Podolec, P Musial, W Drelich, G Kania, G Miekus, P Mazur, S Janik, A Spyra, J Peruga, J Balsam, P Krakowiak, B Szachniewicz, J Ginel, M Grzybowski, J Chrustowski, W Wojewoda, P Kalinka, A Zurakowski, A Koc, R Debinski, M Fil, W Kujawiak, M Forys, J Kasprzak, M Krol, M Michalski, P Mirek-Bryniarska, E Radwan, K Skonieczny, G Stania, K Skoczylas, G Madej, A Jurowiecki, J Firek, B Wozakowska-Kaplon, B Cymerman, K Neutel, J Adams, K Balfour, P Deswal, A Djamson, A Duncan, P Hong, M Murray, C Rinde-Hoffman, D Woodhouse, S MacNevin, R Rama, B Anderson, K Broome-Webster, C Kindsvater, S Abramov, D Barettella, M Pinney, S Herre, J Cohen, A Vora, K Challappa, K West, S Baum, S Cox, J Jani, S Karim, A Akhtar, A Quintana, O Paukman, L Goldberg, R Bhatti, Z Budoff, M Bush, E Potler, A Delgado, R Ellis, B Dy, J Fialkow, J Sangrigoli, R Ferdinand, K East, C Falkowski, S Donahoe, S Ebrahimi, R Kline, G Harris, B Khouzam, R Jaffrani, N Jarmukli, N Kazemi, N Koren, M Friedman, K Herzog, W Greenberg, B Silva Enciso, J Cheung, D Grover-McKay, M Hauptman, P Mikhalkova, D Hegde, V Hodsden, J Khouri, S McGrew, F McCullough, P Littlefield, R Bradley, P McLaurin, B Lupovitch, S Labin, I Rao, V Leithe, M Lesko, M Lewis, N Lombardo, D Mahal, S Malhotra, V Mehta, V Dauber, I Banerjee, A Needell, J Miller, G Paladino, L Munuswamy, K Nanna, M McMillan, E Mumma, M Napoli, M Nelson, W O'Brien, T Adlakha, A Onwuanyi, A Serota, H Schmedtje, J Paraschos, A Potu, R Sai-Sudhakar, C Saltzberg, M Sauer, A Shah, P Skopicki, H Bui, H Carr, K Stevens, G Tahirkheli, N Tallaj, J Yousuf, K Trichon, B Welker, J Tolerico, P Vest, A Vivo, R Wang, X Abadier, R Dunlap, S Weintraub, N Malik, A Kotha, P Zaha, V Kim, G Uriel, N Greene, T Salacata, A Arora, R Gazmuri, R Kobayashi, J Iteld, B Vijayakrishnan, R Dab, R Mirza, Z Marques, V Nallasivan, M Bensimhon, D Peart, B Saint-Jacques, H Barringhaus, K Contreras, J Gupta, A Koneru, S Nguyen, V
Source :
The Lancet Diabetes & Endocrinology; January 2022, Vol. 10 Issue: 1 p35-45, 11p
Publication Year :
2022
Abstract
It is important to evaluate whether a new treatment for heart failure with reduced ejection fraction (HFrEF) provides additive benefit to background foundational treatments. As such, we aimed to evaluate the efficacy and safety of empagliflozin in patients with HFrEF in addition to baseline treatment with specific doses and combinations of disease-modifying therapies.
Details
Language :
English
ISSN :
22138587 and 22138595
Volume :
10
Issue :
1
Database :
Supplemental Index
Journal :
The Lancet Diabetes & Endocrinology
Publication Type :
Periodical
Accession number :
ejs58388159
Full Text :
https://doi.org/10.1016/S2213-8587(21)00292-8