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Injectable Erythrocyte Gel Loaded with Bulleyaconitine A for the Treatment of Rheumatoid Arthritis
- Source :
- ACS Biomaterials Science & Engineering; 20210101, Issue: Preprints
- Publication Year :
- 2021
-
Abstract
- Rheumatoid arthritis (RA) is a systemic autoimmune disease with clinical manifestations including joint cartilage, synovitis, and bone damage. Here we developed an injectable erythrocyte gel loaded with Bulleyaconitine A (BLA) for the treatment of RA and demonstrated its anti-inflammatory effects in vivoand in vitro. In vitroexperiments showed that BLA could effectively down-regulate the expression of pro-inflammatory factor in activated macrophages through the nuclear factor-κB (NF-κB) pathway. In vivoexperiments have shown that the injection of BLA@RBCs in the inflammatory joints of CIA mice increases the local concentration of BLA in a long time. Improved therapeutic outcomes and reduced toxicity of BLA are demonstrated in our work. Together, the developed BLA@RBCs drug delivery system provides an alternative strategy to treat RA joints and shows high potential in clinical RA treatment.
Details
- Language :
- English
- ISSN :
- 23739878
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- ACS Biomaterials Science & Engineering
- Publication Type :
- Periodical
- Accession number :
- ejs58367264
- Full Text :
- https://doi.org/10.1021/acsbiomaterials.1c01175