Back to Search Start Over

A novel fluorescent c-met targeted imaging agent for intra-operative colonic tumour mapping: Translation from the laboratory into a clinical trial

Authors :
Armstrong, Gemma R.
Khot, Mohammed I.
Portal, Christophe
West, Nick P.
Perry, Sarah L.
Maisey, Tom I.
Tiernan, Jim P.
Hughes, Thomas A.
Tolan, Damian J.
Jayne, David G.
Source :
Surgical Oncology; March 2022, Vol. 40 Issue: 1
Publication Year :
2022

Abstract

The c-Met protein is overexpressed in many gastrointestinal cancers. We explored EMI-137, a novel c-Met targeting fluorescent probe, for application in fluorescence-guided colon surgery, in HT-29 colorectal cancer (CRC) cell line and an in vivomurine model.

Details

Language :
English
ISSN :
09607404
Volume :
40
Issue :
1
Database :
Supplemental Index
Journal :
Surgical Oncology
Publication Type :
Periodical
Accession number :
ejs58326520
Full Text :
https://doi.org/10.1016/j.suronc.2021.101679