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Response to treatment in NMOSD: the Australasian experience

Authors :
Clarke, Laura
Bukhari, Wajih
O'Gorman, Cullen M.
Khalilidehkordi, Elham
Arnett, Simon
Woodhall, Mark
Prain, Kerri M.
Parratt, John D.E.
Barnett, Michael H.
Marriott, Mark P.
McCombe, Pamela A.
Sutton, Ian
Boggild, Mike
Brownlee, Wallace
Carroll, William M.
Hodgkinson, Suzanne
Macdonell, Richard A.L.
Mason, Deborah F.
Pereira, Jennifer
Slee, Mark
Das, Chandi
Henderson, Andrew P.D.
Kermode, Allan G.
Lechner-Scott, Jeannette
Waters, Patrick
Sun, Jing
Broadley, Simon A.
Source :
Multiple Sclerosis and Related Disorders; 20210101, Issue: Preprints
Publication Year :
2021

Abstract

•Retrospective study of treatment outcomes in AQP4 Ab positive NMOSD.•Rituximab is associated with reduced ARR compared to no treatment, beta-interferon and standard immunosuppressive therapy.•Compared to other therapies rituximab reduces risk in time to first relapse survival analyses.•Rituximab and immunosuppressive therapy are associated with a lower final EDSS score.•Rituximab should be considered as first-line therapy in AQP4 Ab positive NMOSD.

Details

Language :
English
ISSN :
22110348
Issue :
Preprints
Database :
Supplemental Index
Journal :
Multiple Sclerosis and Related Disorders
Publication Type :
Periodical
Accession number :
ejs58311398
Full Text :
https://doi.org/10.1016/j.msard.2021.103408