Rebound activity after fingolimod cessation: a case – control study

•The median time to rebound activity after fingolimod discontinuation was 50 days (IQR 37.25 – 86.75).•The main reason for stopping fingolimod in this cohort was therapeutic failure (46%).•Age, gender, MS phenotype, number of relapses in the year prior to suspension, time of exposure to fingolimod, or EDSS at the moment of suspension, were not predictors of RA.•68% of cases developed sustained worsening in EDSS after 3 months of RA.