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Shikonin contributes to intestinal epithelial cell differentiation through PKM2/NRF2-mediated Polyol pathway
- Source :
- Pharmacological Research - Modern Chinese Medicine; December 2021, Vol. 1 Issue: 1
- Publication Year :
- 2021
-
Abstract
- Alteration of polyol pathway is a critical event in serials of disease, including inflammatory bowel disease (IBD). Shikonin, an inhibitor of PKM2, has been reported to exert a wide range of biological and pharmacological properties. However, the function of shikonin-mediated polyol pathway in IBD remained to be addressed.
Details
- Language :
- English
- ISSN :
- 26671425
- Volume :
- 1
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Pharmacological Research - Modern Chinese Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs57921344
- Full Text :
- https://doi.org/10.1016/j.prmcm.2021.100004