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Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors
- Source :
- Molecular and Cellular Biology; November 1986, Vol. 6 Issue: 11 p4104-4108, 5p
- Publication Year :
- 1986
-
Abstract
- Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.
Details
- Language :
- English
- ISSN :
- 02707306 and 10985549
- Volume :
- 6
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Molecular and Cellular Biology
- Publication Type :
- Periodical
- Accession number :
- ejs57790478
- Full Text :
- https://doi.org/10.1128/mcb.6.11.4104-4108.1986