Fatal Invasive Infection with Fungemia Due to Microascus cirrosusafter Heart and Lung Transplantation in a Patient with Cystic Fibrosis

ABSTRACTScopulariopsisspecies are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsisspecies, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascusinfections are discussed.