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The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

Authors :
Wang, Ling
Howell, Mary E. A.
Sparks-Wallace, Ayrianna
Zhao, Juan
Hensley, Culton R.
Nicksic, Camri A.
Horne, Shanna R.
Mohr, Kaylea B.
Moorman, Jonathan P.
Yao, Zhi Q.
Ning, Shunbin
Source :
mBio; September 2021, Vol. 12 Issue: 5
Publication Year :
2021

Abstract

As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.

Details

Language :
English
ISSN :
21612129 and 21507511
Volume :
12
Issue :
5
Database :
Supplemental Index
Journal :
mBio
Publication Type :
Periodical
Accession number :
ejs57732546
Full Text :
https://doi.org/10.1128/mBio.01097-21