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Isolation and Characterization of a sigBDeletion Mutant of Staphylococcus aureus
- Source :
- Infection and Immunity; July 1999, Vol. 67 Issue: 7 p3667-3669, 3p
- Publication Year :
- 1999
-
Abstract
- ABSTRACTThe sigBgene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mutant showed no reduction in virulence.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 67
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs57553365
- Full Text :
- https://doi.org/10.1128/IAI.67.7.3667-3669.1999