LcrG is Required for Efficient Translocation ofYersiniaYop Effector Proteins into Eukaryotic Cells

ABSTRACTExtracellular Yersiniadisables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocoliticanonpolar lcrGmutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.