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The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus
- Source :
- Cell Reports; August 2021, Vol. 36 Issue: 8
- Publication Year :
- 2021
-
Abstract
- Radial glia-like (RGL) stem cells persist in the adult mammalian hippocampus, where they generate new neurons and astrocytes throughout life. The process of adult neurogenesis is well documented, but cell-autonomous factors regulating neuronal and astroglial differentiation are incompletely understood. Here, we evaluate the functions of the transcription factor zinc-finger E-box binding homeobox 1 (ZEB1) in adult hippocampal RGL cells using a conditional-inducible mouse model. We find that ZEB1 is necessary for self-renewal of active RGL cells. Genetic deletion of Zeb1causes a shift toward symmetric cell division that consumes the RGL cell and generates pro-neuronal progenies, resulting in an increase of newborn neurons and a decrease of newly generated astrocytes. We identify ZEB1 as positive regulator of the ets-domain transcription factor ETV5 that is critical for asymmetric division.
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 36
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs57505096
- Full Text :
- https://doi.org/10.1016/j.celrep.2021.109588