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Construction of Bulky Ligand Libraries by Ru(II)-Catalyzed P(III)-Assisted ortho-C–H Secondary Alkylation
- Source :
- The Journal of Organic Chemistry; September 2021, Vol. 86 Issue: 17 p11915-11925, 11p
- Publication Year :
- 2021
-
Abstract
- Modification of commercially available biaryl monophosphine ligands via ruthenium(II)-catalyzed P(III)-directed-catalyzed ortho C–H secondary alkylation is described. The use of highly ring-strained norbornene as a secondary alkylating reagent is the key to this transformation. A series of highly bulky ligands with a norbornyl group were obtained in excellent yields. The modified ligands with secondary alkyl group outperformed common substituted phosphines in the Suzuki–Miyaura cross-coupling reaction at a ppm mole level of Pd catalyst.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 86
- Issue :
- 17
- Database :
- Supplemental Index
- Journal :
- The Journal of Organic Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs57492314
- Full Text :
- https://doi.org/10.1021/acs.joc.1c01329