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A Murine Model for Enhancement of Streptococcus pneumoniaePathogenicity upon Viral Infection and Advanced Age
- Source :
- Infection and Immunity; May 2021, Vol. 89 Issue: 8
- Publication Year :
- 2021
-
Abstract
- Streptococcus pneumoniae(pneumococcus) resides asymptomatically in the nasopharynx (NP) but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation with influenza A virus (IAV) but did not fully recapitulate the severe disease associated with human coinfection.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 89
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs57484546
- Full Text :
- https://doi.org/10.1128/IAI.00471-20