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AMG 900, a Potent and Highly Selective Aurora Kinase Inhibitor Shows Promising Preclinical Activity Against Acute Myeloid Leukemia Cell Lines In Vitroand In Vivo
- Source :
- Blood; November 2013, Vol. 122 Issue: 21 p3823-3823, 1p
- Publication Year :
- 2013
-
Abstract
- Aurora kinases A and B play essential roles in multiple stages of mitosis and are frequently overexpressed in a subset of human cancers, including acute myeloid leukemia (AML) (Ikezoe T et al, 2007). AMG 900, a potent and highly selective small molecule inhibitor of aurora kinases, is currently in Phase 1 clinical testing in adult patients with AML.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 122
- Issue :
- 21
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs57446056
- Full Text :
- https://doi.org/10.1182/blood.V122.21.3823.3823