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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells
- Source :
- Antimicrobial Agents and Chemotherapy; July 2021, Vol. 65 Issue: 9
- Publication Year :
- 2021
-
Abstract
- Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine analogue. RDV is taken up in the target cells and metabolized in multiple steps to form the active nucleoside triphosphate (TP) (GS-443902), which, in turn, acts as a potent and selective inhibitor of multiple viral RNA polymerases.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 65
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs57441893
- Full Text :
- https://doi.org/10.1128/AAC.00602-21