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Interferon γ Stabilizes the T Helper Cell Type 1 Phenotype
- Source :
- The Journal of Experimental Medicine; July 2001, Vol. 194 Issue: 2 p165-172, 8p
- Publication Year :
- 2001
-
Abstract
- T helper cell (Th)1-primed CD4 T cells from wild-type donors make little interleukin (IL)-4 when restimulated under Th2 conditions. However, such restimulation of Th1-primed cells from interferon (IFN)-γ2/− or IFN-γ receptor (IFN-γR)−/− mice resulted in substantial production of IL-4 and other Th2 cytokines. Adding IFN-γ to the priming culture markedly diminished the capacity of Th1-primed IFN-γ2/− cells to express IL-4. Even IFN-γ–producing cells from IFN-γR−/− mice could acquire IL-4–producing capacity. Thus, IFN-γ is not required for the development of IFN-γ–producing capacity, but it plays a critical role in suppressing the IL-4–producing potential of Th1 cells.
Details
- Language :
- English
- ISSN :
- 00221007 and 15409538
- Volume :
- 194
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- The Journal of Experimental Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs57373200
- Full Text :
- https://doi.org/10.1084/jem.194.2.165