Immunotherapy with Tacrolimus (FK506) Does Not Select for Resistance to Calcineurin Inhibitors in Candida albicansIsolates from Liver Transplant Patients

ABSTRACTIn Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candidaisolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.