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mmpL7Gene of Mycobacterium tuberculosisIs Responsible for Isoniazid Efflux in Mycobacterium smegmatis
- Source :
- Antimicrobial Agents and Chemotherapy; November 2005, Vol. 49 Issue: 11 p4775-4777, 3p
- Publication Year :
- 2005
-
Abstract
- ABSTRACTThe Mycobacterium tuberculosis mmpL7gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatiscells expressing the mmpL7gene was observed.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 49
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs57150594
- Full Text :
- https://doi.org/10.1128/AAC.49.11.4775-4777.2005