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G484S Amino Acid Substitution in Lanosterol 14-α Demethylase (ERG11) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformansClinical Isolate
- Source :
- Antimicrobial Agents and Chemotherapy; November 2003, Vol. 47 Issue: 11 p3653-3656, 4p
- Publication Year :
- 2003
-
Abstract
- ABSTRACTFive sequential Cryptococcus neoformansisolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-α lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 47
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs57149604
- Full Text :
- https://doi.org/10.1128/AAC.47.11.3653-3656.2003