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Penetration of vancomycin in uninfected sternal bone
- Source :
- Antimicrobial Agents and Chemotherapy; November 1992, Vol. 36 Issue: 11 p2539-2541, 3p
- Publication Year :
- 1992
-
Abstract
- Concentrations of vancomycin in sternal bones of 10 patients undergoing cardiac surgery were studied at steady state, 48 h after starting intravenous prophylaxis. A sample of sternal bone was taken before (group I) or after (group II) cardiopulmonary bypass. The mean vancomycin concentrations in sternal bones were not significantly different between the groups and were 9.3 +/- 3.0 micrograms/g. The concentrations of vancomycin in sternal bones were always above the MICs for staphylococci, streptococci, and enterococci.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 36
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs57142999
- Full Text :
- https://doi.org/10.1128/AAC.36.11.2539