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Diffuse Osteosclerosis in Hairy Cell Leukemia

Authors :
VanderMolen, Louis A.
Urba, Walter J.
Longo, Dan L.
Lawrence, Jeffry
Gralnick, Harvey
Steis, Ronald G.
Source :
Blood; November 1989, Vol. 74 Issue: 6 p2066-2069, 4p
Publication Year :
1989

Abstract

We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatment of her hairy cell leukemia with interferon alpha and deoxycoformycin suggesting that the osteosclerosis observed was related to the underlying malignant disease. Possible étiologie mechanisms are discussed.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
74
Issue :
6
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs57133183
Full Text :
https://doi.org/10.1182/blood.V74.6.2066.2066