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Photoredox Generation of N-Centered Hydrazonyl Radicals Enables the Construction of Dihydropyrazole-Fused gem-Difluoroalkenes
- Source :
- Organic Letters; August 2021, Vol. 23 Issue: 15 p6153-6157, 5p
- Publication Year :
- 2021
-
Abstract
- An efficient visible-light-promoted N-radical-mediated tandem radical cyclization/defluorinated alkylation of β,γ-unsaturated hydrazones, and α-trifluoromethyl alkenes is described. This protocol provides a general and effective route to synthesize various dihydropyrazole-fused gem-difluoroalkenes at moderate to excellent yields under redox-neutral, metal-free, and mild conditions.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 23
- Issue :
- 15
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs57127519
- Full Text :
- https://doi.org/10.1021/acs.orglett.1c02275