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High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells

Authors :
Takihara, Yuji
Nakamura-Ishizu, Ayako
Tan, Darren Qiancheng
Fukuda, Masahiro
Matsumura, Takayoshi
Endoh, Mitsuhiro
Arima, Yuichiro
Chin, Desmond Wai Loon
Umemoto, Terumasa
Hashimoto, Michihiro
Mizuno, Hidenobu
Suda, Toshio
Source :
Blood Advances; August 2019, Vol. 3 Issue: 15 p2323-2327, 5p
Publication Year :
2019

Abstract

•HSCs can be separated based on high or low mitochondrial mass.•Higher mitochondrial mass is associated with quiescence and greater reconstitution capacity of HSCs.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
3
Issue :
15
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs57058913
Full Text :
https://doi.org/10.1182/bloodadvances.2019032169