p53 and p16ink4aAs Predictive and Prognostic Biomarkers for Nodal metastasis and Survival in A Contemporary Cohort of Penile Squamous Cell Carcinoma

Human papilloma virus (HPV) infection is implicated in a proportion of invasive squamous cell carcinoma of the penis (PC). A subset of PC involves dysregulation of the p53pathway. HPV in situ hybridization (ISH) and p16ink4apositivity are surrogate markers for HPV infection, and p53 immunohistochemistry (IHC) denotes abnormality in the p53pathway. There remains an ambiguity with regard to the contribution of both the pathways in the prognosis of PC. We sought to analyze the clinicopathologic characteristics of a cohort of Indian PC patients with respect to p16 ink4aand p53 expression.