Polymorphisms In IRS1and IL6Rand Susceptibility To Multiple Myeloma

The etiology of multiple myeloma remains unknown, but some heritable contribution is suspected. Very few genetic risk markers have been reported in more than one study population. A nested analysis (72 cases, 144 controls) in the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS) cohorts suggested a role in multiple myeloma susceptibility for single nucleotide polymorphisms (SNP) in the genes for the insulin receptor substrate type 1 (IRS1; rs17208470, rs1801278) and the interleukin (IL)-6 receptor (IL6R; rs6684439, rs7529229, rs2228145). The NHS and HPFS cohort members are predominantly of European origin; the present analysis further explored the IRS1 and IL6R loci in persons of European descent and in African Americans in a large pooled population comprised of five U.S. population-based studies.