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A Quantitative and Confirmatory Method Employing Liquid Chromatography Coupled to Hybrid High-Resolution Mass Spectrometry and QuEChERS for the Determination of Thirty-Seven Growth Promoter Residues in Bovine Urine
- Source :
- Journal of Agricultural and Food Chemistry; July 2021, Vol. 69 Issue: 28 p7990-7996, 7p
- Publication Year :
- 2021
-
Abstract
- In this work, 37 growth promoters were quantitatively determined in bovine urine using a QuEChERS approach with acetonitrile, NaCl, and MgSO4:PSA for sample extraction. The analytes were separated and detected by liquid chromatography coupled to hybrid high-resolution mass spectrometry. The method was validated in accordance with the Decision 657/2002/EC guidelines, in which recoveries fell within the range 84–113%, relative standard varied between 2 and 32%, and detection limit between 0.1 and 2.5 μg L–1. An adequate performance was evidenced during a proficiency test evaluation, and the developed method has been applied to routine analysis of growth promoters in Brazil. A highlight is the easiness of sample extraction combined with a quantitative determination of forbidden drugs using high-resolution mass spectrometry, which enables retrospective analysis in a surveillance perspective.
Details
- Language :
- English
- ISSN :
- 00218561 and 15205118
- Volume :
- 69
- Issue :
- 28
- Database :
- Supplemental Index
- Journal :
- Journal of Agricultural and Food Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs57002704
- Full Text :
- https://doi.org/10.1021/acs.jafc.1c02286