NUP98is fused to the NSD3gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)

Fusion between the NUP98and NSD3genes in a patient with acute myeloid leukemia associated with t(8;11)(p11.2;p15), is reported for the first time. The t(8;11)(p11.2;p15) was identified by classical cytogenetics. Fluorescence in situ hybridization (FISH) analysis revealed a split signal with a mix of BAC 118H17 and 290A12, indicating the translocation disrupted NUP98. FISH restriction at 8p11-12 showed a split of BAC 350N15. Molecular investigations into candidate genes in this BAC showed the NUP98fusion partner at 8p11.2 was the NSD3gene. To date the NSD3gene has never been implicated in hematologic malignancies.