Chromosomal Aberrations in Polycythemia Vera

A number of chromosomal aberrations, occurring in polycythemia vera patients are presented, with an emphasis on their nonspecific nature. Among radiophosphorus-treated patients the frequency of these aberrations was moderately higher. The one finding typical to P32treated patients was the presence of dicentric chromosomes, and a dose response curve to the last P32dose was demonstrated. A Philadelphia-like chromosome was observed in two patients with polycythemia vera and in one with benign erythrocytosis, all post P32therapy.