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HIV-1 and human genetic variation
- Source :
- Nature Reviews Genetics; October 2021, Vol. 22 Issue: 10 p645-657, 13p
- Publication Year :
- 2021
-
Abstract
- Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV infection, has progressed from early candidate gene studies to recent multi-omic efforts, benefiting from spectacular advances in sequencing technology and data science. In addition to invading cells and co-opting the host machinery for replication, HIV also stably integrates into our own genome. The study of the complex interactions between the human and retroviral genomes has improved our understanding of pathogenic mechanisms and suggested novel preventive and therapeutic approaches against HIV infection.
Details
- Language :
- English
- ISSN :
- 14710056 and 14710064
- Volume :
- 22
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Nature Reviews Genetics
- Publication Type :
- Periodical
- Accession number :
- ejs56914261
- Full Text :
- https://doi.org/10.1038/s41576-021-00378-0