Importance of DNMT3A Gene mutationsdetection in Prognostic Analyses of Patients with Acute Myeloid Leukemia

Objectives and background:Normal karyotype (NK) in AML patients accounts for nearly 45% of all cases and were assigned into intermediate risk group. The identification of new molecular markers in this group is the focus of most of researches. The application of the next-generation sequence techniques led to detect molecular markers with valuable prognostic significance. F.e., identification of DNMT3Amutations has gained the tremendous attention in recent times, because of its essential role in cell development, high frequency in AML patients and association of poor clinical outcome. Objects: to analyse character and frequency of DNMT3Amutations in AML patients; to study their associations with clinical and laboratory parameters and other molecular markers; to investigate their prognostic value.