Programmed Necrosis Correlates with Development and Progression of Myelodysplastic Syndromes

Myelodysplastic syndrome (MDS) is characterized by persistent cytopenias and evidence of morphologic dysplasia in the bone marrow. Lower-grade MDS (bone marrow blasts <5%) is challenging to diagnose, as the morphologic dysplasia may be subtle and many patients lack characteristic cytogenetic abnormalities.