Low Expression of T/NK-Cell Signature Predicts Poor Survival in Patients with Primary Testicular and Diffuse Large B-Cell Lymphoma

Primary testicular lymphoma (PTL) is a rare and aggressive disease accounting for 1% of malignant lymphomas. Majority of the PTLs are diffuse large B-cell lymphomas (DLBCL). Recently, the impact of tumor microenvironment (TME) and limited immune surveillance on the lymphoma pathogenesis and survival has been recognized. Here, we aimed to characterize cellular and molecular immunological profiles in PTL, and associate the findings with outcome.