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Select Peripheral Blood Cytokine Levels Are Associated with Survival in Pediatric Acute Myeloid Leukemia

Authors :
Stevens, Alexandra McLean
Horton, Terzah M.
Redell, Michele
Source :
Blood; December 2017, Vol. 130 Issue: 1, Number 1 Supplement 1 p2690-2690, 1p
Publication Year :
2017

Abstract

Background: Risk stratification for pediatric AML currently relies on response to therapy and a small number of prognostic genetic factors. With these limited criteria, approximately 75% of children are initially classified as being at a lower risk (LR) of relapse. However, 30% of LR patients relapse, and achieving a second remission is often quite difficult. Therefore, there is an urgent need improve risk stratification in pediatric AML. Cytokine levels have been shown to predict outcome in adult AML but have not been extensively studied in pediatric AML, in part due to lack of available samples. We utilized a unique repository of diagnostic peripheral blood (PB) plasma from pediatric AML patients to quantify cytokine levels and determine associations with outcome.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
130
Issue :
1, Number 1 Supplement 1
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs56856234
Full Text :
https://doi.org/10.1182/blood.V130.Suppl_1.2690.2690