Interaction of Human Platelets with Enterohemorrhagic E. coliO111, Induces an Increase in the Procoagulant Activity, Thrombin Generation and Adhesion to Endothelial Cells

Acute inflammation in response to severe bacterial infection, results in hemostatic abnormalities ranging from subclinical to sustained systemic clotting activation leading to massive thrombin and fibrin formation and microvascular thrombosis. Endothelial activation and dysfunction are critical determinants of the host response and provide an explanation for the different abnormalities involved in the pathophysiology of sepsis.