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Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies
- Source :
- Nukleonika; June 2021, Vol. 66 Issue: 2 p61-67, 7p
- Publication Year :
- 2021
-
Abstract
- Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl2target may provide a feasible design outline for an Ac-225 generator.
Details
- Language :
- English
- ISSN :
- 00295922 and 15085791
- Volume :
- 66
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Nukleonika
- Publication Type :
- Periodical
- Accession number :
- ejs56648570
- Full Text :
- https://doi.org/10.2478/nuka-2021-0008