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Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial

Authors :
Lopes, Renato D
de Barros e Silva, Pedro Gabriel Melo
Furtado, Remo H M
Macedo, Ariane Vieira Scarlatelli
Bronhara, Bruna
Damiani, Lucas Petri
Barbosa, Lilian Mazza
de Aveiro Morata, Júlia
Ramacciotti, Eduardo
de Aquino Martins, Priscilla
de Oliveira, Aryadne Lyrio
Nunes, Vinicius Santana
Ritt, Luiz Eduardo Fonteles
Rocha, Ana Thereza
Tramujas, Lucas
Santos, Sueli V
Diaz, Dario Rafael Abregu
Viana, Lorena Souza
Melro, Lívia Maria Garcia
de Alcântara Chaud, Mariana Silveira
Figueiredo, Estêvão Lanna
Neuenschwander, Fernando Carvalho
Dracoulakis, Marianna Deway Andrade
Lima, Rodolfo Godinho Souza Dourado
de Souza Dantas, Vicente Cés
Fernandes, Anne Cristine Silva
Gebara, Otávio Celso Eluf
Hernandes, Mauro Esteves
Queiroz, Diego Aparecido Rios
Veiga, Viviane C
Canesin, Manoel Fernandes
de Faria, Leonardo Meira
Feitosa-Filho, Gilson Soares
Gazzana, Marcelo Basso
Liporace, Idelzuíta Leandro
de Oliveira Twardowsky, Aline
Maia, Lilia Nigro
Machado, Flávia Ribeiro
de Matos Soeiro, Alexandre
Conceição-Souza, Germano Emílio
Armaganijan, Luciana
Guimarães, Patrícia O
Rosa, Regis G
Azevedo, Luciano C P
Alexander, John H
Avezum, Alvaro
Cavalcanti, Alexandre B
Berwanger, Otavio
Source :
The Lancet; June 2021, Vol. 397 Issue: 10291 p2253-2263, 11p
Publication Year :
2021

Abstract

COVID-19 is associated with a prothrombotic state leading to adverse clinical outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised with COVID-19 is unknown. We aimed to compare the efficacy and safety of therapeutic versus prophylactic anticoagulation in this population.

Details

Language :
English
ISSN :
01406736 and 1474547X
Volume :
397
Issue :
10291
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs56608065
Full Text :
https://doi.org/10.1016/S0140-6736(21)01203-4
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