Back to Search
Start Over
Creating a Population Model for PK-Tailored Dosing Using Real-World Data from the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Platform
- Source :
- Blood; November 2018, Vol. 132 Issue: 1, Number 1 Supplement 1 p1191-1191, 1p
- Publication Year :
- 2018
-
Abstract
- Objective: The Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) platform allows hemophilia treaters to estimate individual PK parameters for clotting factor concentrates using only a few blood samples drawn from their patients. Population pharmacokinetic (PopPK) models used with WAPPS-Hemo are usually built using clinical trial data provided by drug manufacturers. These trials can be restrictive with respect to patient covariates such as age and body weight. On the other hand, real-world pharmacokinetic data submitted to WAPPS captures the breadth of hemophilia patients. We tested the use of post-infusion clotting factor concentrate measurements collected through routine use of WAPPS-Hemo to develop a plasma-derived FVIII (Fanhdi/Alphanate)-specific model for which no trial data was available.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 132
- Issue :
- 1, Number 1 Supplement 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs56583849
- Full Text :
- https://doi.org/10.1182/blood-2018-99-115308