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Budesonide mixed with surfactant did not affect neurodevelopmental outcomes at 6 or 18 months corrected age in observational cohorts
- Source :
- Journal of Perinatology; 20240101, Issue: Preprints p1-9, 9p
- Publication Year :
- 2024
-
Abstract
- Background: The addition of budesonide to surfactant in very-low-birth-weight infants with less severe RDS decreased bronchopulmonary dysplasia (BPD) severity. Long-term neurodevelopmental follow-up was needed to monitor for systemic effects of budesonide. Methods: Infants ≤1250 g who received intratracheal budesonide (0.25 mg/kg) with surfactant (n= 173) were compared to a historical cohort who received surfactant alone (n= 294). Peabody Developmental Motor Scales II at 4–6 months corrected age and Bayley Scales of Infant & Toddler Development III at 18–22 months corrected age were compared. Results: There were no differences in muscle tone or motor skills by Peabody exam. There were no differences in the cognitive, language, or motor domains between cohorts on Bayley III. Conclusions: In a cohort of infants treated with budesonide mixed with surfactant, there were no differences in developmental outcomes at 4–6 months or 18–22 months corrected age.
Details
- Language :
- English
- ISSN :
- 07438346 and 14765543
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Perinatology
- Publication Type :
- Periodical
- Accession number :
- ejs56316295
- Full Text :
- https://doi.org/10.1038/s41372-021-01066-x