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Successful treatment with adapted high dose methotrexate in a hemodialysis patient with primary central nervous system lymphoma: 100mg/m2seems sufficient

Authors :
Solignac, Justine
Farnault, Laure
Robert, Thomas
Fanciullino, Raphaelle
Choquet, Sylvain
Brunet, Philippe
Venton, Geoffroy
Bobot, Mickaël
Source :
Nefrología; March-April 2022, Vol. 42 Issue: 2 p130-134, 5p
Publication Year :
2022

Abstract

High dose methotrexate (HD-MTX) based chemoimmunotherapy is a central part of the standard approach to treatment of primary central nervous system lymphoma (PCNSL). Renal dysfunction leads to delayed MTX complete elimination and critical MTX concentration. Despite the recommendations, hemodialysis status should not exclude HD-MTX.

Details

Language :
English
ISSN :
02116995 and 19892284
Volume :
42
Issue :
2
Database :
Supplemental Index
Journal :
Nefrología
Publication Type :
Periodical
Accession number :
ejs56264297
Full Text :
https://doi.org/10.1016/j.nefro.2021.03.004