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Platinum(IV) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines
- Source :
- Journal of Medicinal Chemistry; January 2004, Vol. 47 Issue: 3 p761-763, 3p
- Publication Year :
- 2004
-
Abstract
- Procedure of the synthesis is described for new platinum(IV) drug LA-12 [(OC-6−43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H<INF>2</INF>O molecule that is not a part of the coordination sphere of platinum. This new drug is more reactive with glutathione than cisplatin and is lacking cross-resistance with cisplatin as proven on the panel of cancer cell lines.
Details
- Language :
- English
- ISSN :
- 00222623 and 15204804
- Volume :
- 47
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Medicinal Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs5617882