Back to Search
Start Over
Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway
- Source :
- Journal of Ginseng Research; 20210101, Issue: Preprints
- Publication Year :
- 2021
-
Abstract
- Maternal Toxoplasma gondii(T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondiieffect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondiiinfection during pregnancy have not been investigated.
Details
- Language :
- English
- ISSN :
- 12268453 and 20934947
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Ginseng Research
- Publication Type :
- Periodical
- Accession number :
- ejs56040209
- Full Text :
- https://doi.org/10.1016/j.jgr.2021.04.003