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Phosphorylation affects the ability of tau protein to promote microtubule assembly.
- Source :
- Journal of Biological Chemistry; April 1984, Vol. 259 Issue: 8 p5301-5305, 5p
- Publication Year :
- 1984
-
Abstract
- Tau is a family of closely related proteins known for its ability to copolymerize with tubulin, inducing the formation of microtubules. When tau was stripped of phosphate by treatment with alkaline phosphatase it underwent a pronounced change in electrophoretic mobility, probably reflecting a conformational change. The dephosphorylated tau promoted significantly more rapid and more extensive polymerization of microtubules though there was no obvious difference in the microtubules formed. Partially purified microtubule protein contains a kinase that can rephosphorylate tau.
Details
- Language :
- English
- ISSN :
- 00219258 and 1083351X
- Volume :
- 259
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Journal of Biological Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs55827870
- Full Text :
- https://doi.org/10.1016/S0021-9258(17)42989-9